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Using Algorithm5 in finding structural motifs
Finding structural patterns among the protein structures is of immense
interest for biologists who often look for structural patterns including
the side-chain conformations[14], none of the existing
algorithms address this issue. Biologists often want to search for a
part of the protein structure(sub-structure) in the existing proteins in the PDB. Our Algorithms can easily address this issues since we try to
find substructures which are similar considering the side-chain conformations, so any new sub-structure which the biologists want to search would be just another input to our algorithm, algorithm6 gives details on how we can use algorithms3 to find structural motifs. Later in the experimental details we show the real substructures(Tyrosine phosphorylated substrates[14]) found by this algorithm6.
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Vamsi Kundeti
2007-10-10